CORDIS Project
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This project investigates the regulation of homologous recombination, a critical DNA repair process, in both mitotic and meiotic cells. It focuses on the roles of specific genes in DNA repair mechanisms and their implications for cancer development, utilizing various biochemical and genetic methods.
DNA is a highly reactive molecule that is subject to deliberate, spontaneous and environmental damage.
One of the most catastrophic lesions in DNA is the double-strand break (DSB), which if left unrepaired can result in cell death, infertility, genome instability and cancer.
Homologous recombination (HR) is a largely error-free mechanism of DSB repair that utilizes an intact sister or homologous chromosome as a repair template.
Despite considerable progress in understanding the mechanisms of HR,…
THE FRANCIS CRICK INSTITUTE LIMITED
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