CORDIS Project
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This project investigates the role of DNA repair mechanisms in cancer development, focusing on how certain proteins manage replication stress. The research aims to uncover the molecular processes that protect DNA during replication and their implications for cancer therapy.
Genomic instability is the main driving force of tumourigenesis, as highlighted by the cancer predisposition conferred by mutations in caretaker genes. DNA replication stress has recently received much attention, for its causative role in transformation and as a strategy for cancer therapy.
Besides other mechanisms protecting replicating chromosomes from genotoxic stress, transient fork remodelling into four-way junctions (fork reversal) is emerging as a key transaction to assist template repair…
UNIVERSITAT ZURICH
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