CORDIS Project
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This project aims to improve drug development efficiency by repurposing existing compounds through a novel collaborative filtering approach. It focuses on creating a robust and explainable classification system that connects drug-disease matchings to biological pathways, enhancing the drug discovery process.
In 2021, drug development pipelines last 10 years in average, and cost around $2 billion, while facing high failure rates, as only around 10% of Phase 0 drug candidates reach the commercialization stage.
These issues can be mitigated through drug repurposing, where existent compounds are systematically screened for new therapeutic indications.
Collaborative filtering is a semi-supervised learning framework that leverages known drug-disease matchings to make novel recommendations.
However, prior…
UNIVERSITAET ROSTOCK
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