CORDIS Project
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This project investigates the molecular mechanisms of centromere function, focusing on the deposition of the histone variant CENP-A. By employing biochemical and structural analysis, it aims to understand how CENP-A is integrated into chromatin to ensure accurate chromosome segregation during cell division.
Accurate segregation of the parental genome to the daughter cells during mitosis is essential for cell and organismal viability, protecting against cell death or cellular transformation.
Kinetochores are crucial for accurate chromosome segregation because they link chromosomes to spindle microtubules.
Kinetochores sprout from unique chromosomal loci named centromeres.
In most eukaryotes, centromere specification does not rely on defined DNA sequences.
Rather, centromere specification relies on e…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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