CORDIS Project
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This project explores genetic diversity in the human genome, focusing on how DNA repair mechanisms in oocytes and early embryos contribute to genome stability. It aims to understand the implications of genetic quality on reproductive health and the potential links to infertility and congenital disorders.
Genome evolution is driven by the generation of diversity.
In mammals, genome diversification occurs in germline during the specialised division (meiosis) in gametes, when chromosomes recombine and assort into new haploid sets as they are passed from parent to offspring.
Recently, the traditional view that genome diversification occurs exclusively in the germline has been challenged by findings that mutations in early embryos may cause predisposition to childhood cancers.
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KOBENHAVNS UNIVERSITET
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