CORDIS Project
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This project aims to understand how brain injury affects glial progenitors and their ability to regenerate. By exploring epigenetic changes and lineage decisions, it seeks to develop strategies for brain repair.
Over a million different cell types and billions of connections underlie brain function.
While the embryonic brain glial progenitors generate this cellular diversity, in the adult brain progenitor competence becomes restricted to generation of few cell types.
Thus, any attempt to repair the brain requires knowledge of the rules governing fate decisions within a damaged environment.
We have shown that injury activates an inflammatory transcriptional signature in glial progenitors leading to exit…
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
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