CORDIS Project
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ReaDMe aims to understand how DNA methylation affects gene regulation by studying transcription factors. The project will utilize genomics and proteomics to identify how these modifications influence gene expression in different cell types.
DNA and chromatin modifications are essential for proper control of gene expression during development.
How these marks alter transcriptional programs and modulate binding patterns of sequence specific transcription factors (TF) remains poorly understood.
This currently limits our interpretation of epigenomic maps towards their incorporation into predictive models of gene regulation.ReaDMe has the ambitious goal to systematically define the sensitivity of TFs to local levels of DNA methylation i…
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
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