CORDIS Project
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The REACTIVA project aims to enhance heart regeneration by reactivating a dormant mechanism in adult cardiomyocytes, the heart muscle cells. By identifying and stimulating adult diploid cardiomyocytes, the project seeks to improve the heart's ability to recover from damage and maintain function.
The mammalian heart is a non-regenerative organ due to the extremely limited ability of fully differentiated cardiomyocytes (CMs) to proliferate.
While neonatal hearts still contain mostly diploid CMs and regenerate efficiently, physiological postnatal CM polyploidization/hypertrophy ensures the contractile capacity of the adult myocardium but represents a roadblock to cardiac regeneration.
Due to this limitation, diseases that provoke CM loss, like acute ischemia, frequently lead to heart failu…
CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
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