CORDIS Project
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This project aims to enhance the stability and developmental potential of induced pluripotent stem cells (iPSCs) by investigating the molecular mechanisms of nuclear reprogramming. It employs advanced single-cell technologies to identify and analyze the characteristics of cells that successfully undergo reprogramming.
The direct conversion approach and the generation of induced pluripotent stem cells (iPSCs) provide an invaluable resource of cells for disease modelling, drug screening, and patient-specific cell-based therapy.
However, the directly converted cells are not stable, and the vast majority of iPSCs exhibit poor developmental potential as measured by stringent pluripotency tests.
This suggests that the prevailing method of reprogramming is not ideal and leads to aberrant/incomplete conversion.
To im…
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