CORDIS Project
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This project develops RElocate, a technology to systematically alter the positions of enhancers and promoters within mammalian genomes. It aims to understand how these elements interact and regulate gene expression by tracking functional consequences of their rearrangements.
In mammalian genomes, the enhancers (E) that control a promoter (P) are often scattered over tens to hundreds of kb, and frequently interdigitate with Es that control other nearby Ps.
How such apparently haphazard linear arrangements can result in specific gene regulation is a major puzzle.
Three main constraints are thought to be involved.
First, biochemical compatibility of Es and Ps may ensure that not all Ps respond equally strongly to a given E.
Second, chromatin loops may either facilitate…
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
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