CORDIS Project
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This project investigates the use of Rod-derived Cone Viability Factor (RdCVF) to protect cone photoreceptors in retinal degeneration, specifically in rod-cone dystrophies. By administering RdCVF in rodent models, it aims to preserve central vision and explore its potential for treating other neurodegenerative diseases…
The discovery of RdCVF (Rod-derived Cone Viability Factor) has provided a clue to understanding the secondary loss of cone photoreceptors (and of central and light-adapted vision) following the degeneration of rod photoreceptors as a consequence of mutations expressed only in rods in most cases of rod-cone degenerations (or retinitis pigmentosa :
RP).
In two different rodent models of RP, intraocular administration of RdCVF increased significantly cone survival and function.
Given the unparallel…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Germany, Tuebingen
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
Portugal, Coimbra
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
France, France
Type: Company (for-profit)
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
France, Paris
Type: Research institute
Activity type: Research Organisations
SME: No
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