CORDIS Project
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This project studies clear cell renal cell carcinoma to understand tumor evolution and heterogeneity. By modeling tumor behavior in various systems, it aims to predict clinical outcomes and responses to treatments, identifying potential therapeutic targets.
Kidney cancer is among the 10 most frequently diagnosed cancers and its incidence is rising.
Clear cell Renal Cell Cancer (ccRCC) is the most common subtype and is characterized by early 3p loss.
The deleted region on chromosome 3p harbours a number of tumour suppressor genes namely VHL, PBRM1, SETD2 and BAP1, which are frequently mutated subsequent to 3p loss. TRACERx Renal is a multi-center, longitudinal cohort study, which studies tumour evolution and intratumoural heterogeneity through multi…
THE FRANCIS CRICK INSTITUTE LIMITED
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