CORDIS Project
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This project focuses on developing a novel vaccination strategy to induce broadly neutralizing antibodies against HIV. It utilizes a mammalian display system to evolve candidate vaccine immunogens and assess their ability to elicit immune responses.
This application proposes experiments to address one of the greatest challenges in HIV vaccine research: how can broadly neutralising antibodies be induced by vaccination in humans to target pathogens such as HIV, which are resistant to traditional vaccine approaches?
The researcher and host labs will develop a mammalian display system using lentiviral vectors to express HIV proteins on the surface of mammalian cells and allow the in vitro evolution of different candidate vaccine immunogens in t…
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