CORDIS Project
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This project investigates the role of RAS-mutant subclones in high hyperdiploid acute lymphoblastic leukemia, a common childhood cancer. It aims to characterize these subclones and assess their potential as therapeutic targets using advanced genetic and modeling techniques.
In high hyperdiploid acute lymphoblastic leukemia (HeH ALL), RAS-mutant subclones may represent the “RASwaytoALL”, a critical evolutionary route that fuels leukemic progression.
HeH ALL is the most common subtype of childhood ALL.
Despite its generally favorable prognosis, it remains a major cause of relapse.
Genetically, this leukemia is characterized by the gain of multiple chromosomes (51–68 in total) and an intriguing genetic mystery: single-cell DNA sequencing performed by the host laborato…
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