CORDIS Project
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This project investigates a class of scaffold proteins that interact with mutated RAS proteins in cancer. By targeting these scaffold proteins, the project aims to develop a novel treatment approach for RAS-driven cancers, potentially offering new hope for patients unresponsive to existing therapies.
More than a quarter of all cancers are driven by mutations in the RAS family of genes.
Considering the key role of these oncogenes, and despite intensive effort, no effective anti-RAS strategies have successfully made it to the clinic.
In our ERC-CoG project, we found that a class of scaffold proteins, expressed in cancer, bind to active/mutated forms of RAS proteins to moderate RAS signalling.
Accordingly, we find that loss of one of the scaffolding protein isoforms in RAS-mutant cancers trigge…
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