CORDIS Project
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This project investigates the mammalian Target Of Rapamycin (mTOR) pathway to understand its role in cell growth and longevity. It aims to develop therapeutic strategies for rare genetic diseases linked to mTOR dysfunction, utilizing mouse models to explore various phenotypes and their implications for human health.
The mammalian Target Of Rapamycin (mTOR) is a master regulator of growth. mTOR is a protein kinase that exists in two distinct complexes in the cell and transduces virtually all anabolic signals from the environment: nutrients, such as
glucose and amino acids, growth factor peptides, such as insulin and insulin like growth factors, oxygen, mitochondrial metabolites, energy status. mTOR is required to sustain cell responses to nutrient availability including cell growth,
proliferation, macromolec…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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