CORDIS Project
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This project investigates how the fungal pathogen Candida albicans develops drug resistance through changes in genome ploidy. By studying these mechanisms, it aims to enhance understanding of fungal diversity and inform strategies for treating fungal infections.
Fungi are particularly challenging pathogens; because they and their human hosts are eukaryotes.
We will study how new traits such as drugR arise rapidly using Candida albicans, the most prevalent fungal pathogen of humans.
The work explores the ground-breaking concept that alterations in genome ploidy are prevalent in drugR isolates because these genome states promote persistence and drug resistance.We recently found that C. albicans, thought to be an “obligate diploid”, can form haploids.
This…
TEL AVIV UNIVERSITY
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United States, Rochester Ny
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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