CORDIS Project
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This project aims to develop a rapid screening platform for potassium ion channels, which are important drug targets due to their role in various diseases. The platform will utilize a novel droplet interface bilayer system to facilitate high-throughput screening of ion channels and their blockers.
Of the estimated 400 ion channels encoded in the human genome, ~70 are potassium (K+) channels.
Their implication in a number of human diseases, e.g., cardiac arrhythmia, cystic fibrosis, makes K+ channels relevant drug targets.
Whereas the number of high-resolution structures of membrane proteins has consistently increased over the last few years, their functional characterization using screening approaches has not kept pace with that of water-soluble proteins.
In this context, reliable and inf…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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