CORDIS Project
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This project focuses on understanding mitochondrial function and its role in heart failure. It aims to investigate the mechanisms of mitochondrial quality control and the potential therapeutic targets related to mitochondrial DNA methylation and autophagy.
Heart failure is the leading cause of morbidity and mortality in developed countries including EU.
Novel and efficient therapeutics to treat patient with heart failure have to be developed.
Mitochondria are subcellular organelles that produce energy and dynamic organelles that fuse and divide.
Dysregulated mitochondrial activity results in generation of free radicals which cause damage to cellular components.
We reported that mitochondrial quality control by autophagy is essential for normal car…
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