CORDIS Project
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This project aims to address oxidative stress by identifying its sources and preventing damage caused by reactive oxygen species. It focuses on developing innovative treatments for various diseases, particularly stroke and neurotrauma, while also exploring the beneficial roles of these reactive species in signaling.
Oxidative stress, an excess of radical and other reactive oxygen species (ROS), has been suggested as a major disease mechanism.
However, the major clinical trials using anti-oxidants have been failures, even suggesting serious side effects.
Here, I propose completely different approaches:
First, instead of letting radicals form and then scavenge them we will identify their diseases-relevant sources and prevent their formation or specifically repair the damage caused by ROS.
Second, we will diff…
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