CORDIS Project
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This project explores how radiation affects tumor vasculature and the tumor microenvironment. By using advanced imaging techniques, it aims to understand the vascular response to radiation, which could enhance the effectiveness of radiation therapy in treating tumors.
The tumour microenvironment plays a significant role in regulating tumour growth, metabolism, DNA repair, metastasis and response to therapy including radiation treatment.
In particular, the oxygenation of a tumour greatly affects the response to ionizing radiation as hypoxic cells are more resistant to radiation then normoxic cells.
Conversely radiation influences the microenvironment of the tumour by alterations in the tumour vasculature.
With high single doses of radiation (>15Gy), vascular d…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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