CORDIS Project
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This project investigates the three-dimensional structure of mammalian cell genomes, focusing on a radial gradient of guanine and cytosine density. By developing new techniques for high-resolution genome mapping, it aims to uncover the functional implications of genome architecture and its role in nuclear processes.
In exciting preliminary experiments leveraging our GPSeq method we discovered that the genome of mammalian cells in interphase folds into a steep radial gradient of guanine and cytosine (GC) density, which seems to persist at the level of individual mitotic chromosomes.
However, we still lack a fundamental understanding of how this higher-order 3D genome architecture is established and what its functional implications are.
Here, I go beyond the state-of-the-art and propose that the observed stee…
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Sweden, Stockholm
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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