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RADBLOCK aims to enhance the delivery of radionuclide therapies for tumors overexpressing HER2 receptors. The project combines targeted nanoparticles with techniques to reduce their uptake by immune cells, improving diagnostic and therapeutic outcomes for specific cancers.
The aim of RADBLOCK is to improve nanocarrier-based radionuclide delivery by enhancing targeting and overcoming problem of non-specific uptake of nanoparticles by macrophages in liver and spleen.
For this purpose, two approaches will be used simultaneously: 1) modification of radionuclide-loaded nanoparticles with targeted scaffold proteins, recognizing HER2 receptor expressed by malignant cells; 2) temporal blockade of the cells of the mononuclear phagocyte system (MPS) to decrease elimination…
UPPSALA UNIVERSITET
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