CORDIS Project
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This project aims to identify new therapeutic targets for heart failure following a myocardial infarction. By employing a novel gene screening method using CRISPR technology, it seeks to uncover receptors that influence cardiomyocyte survival and could lead to innovative treatments.
Myocardial Infarction (MI) is the leading cause of heart failure, which represents a major medical, social and economic burden worldwide.
There is a desperate need for new therapies for these conditions.
Here we propose a new approach for the in vivo, unbiased and systematic identification of receptors involved in MI, which might become targets for innovative therapeutics.
The method we developed, named Reverse Functional Selection (R-FunSel) takes advantage of the CRISPR/Cas9 genome editing tec…
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