CORDIS Project
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This project investigates the role of cancer stem cells in glioblastoma, focusing on their cell cycle states and contributions to tumor growth and recurrence. By utilizing mouse models and novel techniques, it aims to clarify how different subpopulations of these cells influence cancer development and treatment resista…
Glioblastoma (GBM) is the most common and aggressive high-grade primary brain tumour in adults.
More than 90% of the patients shows recurrence of the disease with a survival of 2 years despite a multitherapeutic approach consisting of a first surgical resection of the brain lesion followed by radio- and chemo-therapy. GBM patients die because of the cancer relapse that evolve becoming not sensitive to the classical therapies. A sub-population of quiescent/slow cycling cancer stem cells (CSCs) ha…
UNIVERSITA DEGLI STUDI DI TRENTO
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