CORDIS Project
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This project investigates the stability and turnover of Dystrophin, a crucial protein for muscle function, using zebrafish models. By testing various truncated versions of Dystrophin, the aim is to understand their effectiveness in restoring muscle structure and function in Duchenne Muscular Dystrophy.
Dystrophin is a large cytoskeletal protein that makes a bridge between the cytoskeletal actin microfilaments in muscle cells and the extracellular matrix, through the Dystrophin-Dystroglycan complex located at the plasma membrane.
This strong link is responsible for conferring resistance to muscle contraction.
Duchenne Muscular Dystrophy (DMD) is an X-chromosome linked disease caused by a mutation on the Dystrophin gene that results in damage to muscle fibers.
Affected individuals rarely live be…
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