CORDIS Project
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This project aims to understand the mechanisms underlying lysosomal storage diseases, which affect neurological function. By analyzing protein changes in various models, the research seeks to identify cellular consequences of lysosomal storage and potential therapeutic targets.
Lysosomal storage diseases (LSD) are a group of ~ 50 genetic disorders, which mainly affect children. LSDs are clinically heterogeneous but are frequently dominated by progressive neurologic deterioration.
Most patients pass away after years of lingering illness.
In general, the molecular pathogenesis of LSDs is still poorly understood.
To gain insight into disease mechanisms the project investigates cellular proteomic alterations sequentially induced by increasing lysosomal storage.
In vivo and…
UNIVERSITATSKLINIKUM BONN
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