CORDIS Project
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This project investigates how transcription factors locate their target DNA sites in living cells. By utilizing advanced tracking techniques, it aims to explore the mechanisms of protein movement and their interactions with DNA, particularly under stress conditions.
Transcription factors (TFs) are capable to identify their target sites on DNA in a extremely efficient fashion.
The observation that a simple 3D diffusion search cannot account for such efficient targeting has led to different mechanisms to be proposed in the last decades, including compact exploration induced by facilitated diffusion (i.e. combination of 1D sliding and 3D diffusion) or by fractal-like chromatin structure.
Despite the evidence for 1D sliding of TFs on DNA and for fractal nucle…
UNIVERSITA VITA-SALUTE SAN RAFFAELE
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