CORDIS Project
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This project investigates G-quadruplex structures in the human genome, focusing on their role in gene regulation and genome stability. It aims to develop methodologies to study protein interactions with these structures, potentially leading to new insights for cancer treatment.
In the human genome, many G-rich sequences have the potential to form 4-stranded non-canonical secondary structures known as G-quadruplexes (G4s).
G4 structures have been visualized in nuclei by immunofluorescence and mapped genome-wide to regulatory chromatin regions linked to elevated transcription using G4 chromatin immunoprecipitation and high-throughput sequencing (G4 ChIP-seq).
G4s are implicated in gene regulation, DNA replication and genome instability, yet little is known about their pr…
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