CORDIS Project
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This project investigates the role of PYHIN proteins in regulating CD8+ memory T cell responses to influenza A virus. By studying these proteins in immune cells, the project aims to enhance understanding of their potential in developing a universal vaccine against respiratory RNA viruses.
Pyrin and HIN domain (PYHIN) proteins play an integral role in the innate immune response to DNA and RNA viruses via direct detection of viral DNA and transcriptional regulation of pro-inflammatory and anti-viral cytokines respectively.
Although expressed by various cells of the myeloid lineage, including some classical antigen presenting cells, the role of PYHINs in the context of T cell-mediated adaptive immunity has yet to be investigated.
This project aims to elucidate how PYHIN proteins mod…
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
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