CORDIS Project
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This project investigates the regeneration of Purkinje cells in zebrafish, focusing on the cellular mechanisms involved. By employing a specific ablation technique, the research aims to uncover insights into neuronal regeneration processes that could inform treatments for cerebellar degenerative diseases.
There are many degenerative diseases affecting the cerebellum (as certain cerebellar ataxia) with severe locomotor symptoms, in which the Purkinje cells (PCs), the sole-output cerebellar neurons, suffer from degeneration.
The adult regenerative capacity of neurons in mammals is extremely low.
However, the zebrafish is a model organism that exhibits extensive adult neurogenesis and regeneration, and is therefore most likely to elucidate key cerebellar regenerative mechanisms that are currently un…
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