CORDIS Project
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This project investigates the molecular mechanisms behind chronic pulmonary hypertension by focusing on specific transcription factors that regulate vascular remodeling. Using advanced genetic techniques, it aims to identify potential therapeutic strategies to reverse abnormal lung vascular changes associated with this…
Chronic pulmonary hypertension (PH) is a lethal disease characterized by the accumulation of persistently activated cell types in the pulmonary vasculature, exhibiting aberrant expression of genes driving apoptosis resistance, proliferation, inflammation and matrix remodeling.
Current vasodilatory therapies for PH do not normalize these activated phenotypes. I have performed an “integromics” approach – combining epigenetic and transcriptional analyses to comprehensively elucidate the underlying…
JUSTUS-LIEBIG-UNIVERSITAET GIESSEN
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