CORDIS Project
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This project investigates how post-translational modifications (PTMs) interact and regulate protein functions in response to environmental stress. By creating a large number of PTM-mutants, the research aims to uncover the complex relationships between PTMs and their regulatory roles in cellular processes.
Post-translational modifications (PTMs) regulate all aspects of protein functionality.
Dysregulation of PTMs or the enzymes that regulate them is frequently associated with disease.
Far from working in isolation, PTMs crosstalk with each other creating decision-making circuits that regulate the cellular adaptation to fluctuating environments. PTM crosstalk is a regulatory layer of the proteome across the tree of life.
However, to what extent and how PTM crosstalk regulates biological processes i…
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