CORDIS Project
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This project develops a high-throughput profiling tool for monitoring ubiquitination in clinical samples, particularly liquid biopsies. It aims to enhance the understanding of ubiquitin-related processes in diseases like autoimmunity and cancer, facilitating the discovery of new diagnostics and therapeutic agents.
Ubiquitination is a post-translational modification (PTM) that is critical for numerous biological processes, including cell cycle, autoimmunity, immune responses, and cancer.
This has instigated vast interest in targeting the ubiquitin machinery, and in elucidating ubiquitin-dependent events in pathologies.
However, a key constraint is the lack of high-throughput methodologies for monitoring ubiquitination in clinical samples.
Current tools mostly provide a qualitative sense of ubiquitin substr…
WEIZMANN INSTITUTE OF SCIENCE
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