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The PROVIDE project aims to enhance the delivery of therapeutic proteins to target cells using engineered extracellular vesicles. By displaying specific membrane proteins on these vesicles, the project seeks to improve targeting, pharmacokinetics, and membrane fusion for effective in vivo treatments.
Genetically modified cells have revolutionized disease treatments by harnessing the power of the immune system.
However, these approaches present challenges, including limited control over cell interactions, significant safety concerns, and the need to genetically engineer cells ex vivo.
In PROVIDE, I propose a conceptually novel approach to engineer cells in vivo by delivering specific membrane proteins to target cells using extracellular vesicles (EVs). EVs are natural mediators of intercellul…
UNIVERZITA KARLOVA
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