CORDIS Project
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This project investigates the role of protein ubiquitylation in DNA repair mechanisms. By analyzing ubiquitin ligase knockdown cells, it aims to identify key substrates involved in maintaining genome integrity, which is crucial for preventing diseases like cancer.
Genome integrity is constantly challenged by endogenous and environmental factors that can induce different types of DNA lesions.
Failure to repair DNA lesions can lead to genomic instability and contribute to human diseases such as cancer and premature ageing.
To counteract these potentially devastating effects caused by DNA damage, eukaryotic cells have evolved complex DNA repair pathways.
Protein ubiquitylation has emerged as an important regulatory mechanism of the cellular response to DNA d…
INSTITUT FUR MOLEKULARE BIOLOGIE GGMBH
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