CORDIS Project
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This project explores how different cell types manage protein folding and health, particularly in the context of diseases like Alzheimer's. It uses real-time sensors to assess the interactions within the proteostasis network across various cell types.
The correct folding and assembly of proteins and protein complexes is essential to cellular function.
Cells have evolved a network of proteins that detect and correct protein damage to maintain proteome health.
However, many protein-misfolding diseases, including Huntington’s and Alzheimer’s diseases, are characterized by the accumulation of damaged proteins with devastating consequences for protein homeostasis (proteostasis), resulting in a collection of deleterious phenotypes and affecting man…
BEN-GURION UNIVERSITY OF THE NEGEV
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