CORDIS Project
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This project introduces a new approach to understanding protein function by analyzing structural changes on a global scale. It aims to identify how protein aggregates affect cellular processes and their potential as biomarkers for diseases like Parkinson's.
Protein expression screens are routinely used to identify biological processes deregulated upon disease development or upon specific cellular perturbations.
Generating molecular hypotheses from these ‘omic data remains challenging, however, and many molecular events that modulate protein function do not involve altered protein levels.
With this project, I propose a new paradigm. I propose that by measuring altered structures of proteins on a global scale, we can capture altered functional states…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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