CORDIS Project
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This project investigates how muscle cells adapt their protein production and degradation to maintain function during exercise and obesity. By studying human and mouse models, it aims to identify key regulators that could improve muscle health and combat obesity-related disorders.
Muscle function is essential for motion, exercise, and shivering, whereas physical inactivity is causally related to reduced metabolic fitness in animal models and humans. A critical requirement for muscle function is that proteins are properly produced and, if necessary, degraded to adapt the proteome to meet metabolic demands.
However, there is a fundamental, open gap in understanding how challenges to muscle proteostasis are sensed and how protein fate is subsequently adapted to enhance muscl…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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