CORDIS Project
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This project focuses on reconstructing ancestral proteins to understand the evolution of protein families. By studying the serum paraoxonase family, it aims to reveal insights into protein function and stability, aiding in protein engineering.
Advances in molecular evolution led to the novel concept of ancestral resurrections, or reconstructions.
These allow the exploration of the mechanisms by which new protein families diverged.
Reconstructed ancestors are also inherently more prone to functional divergence, and exhibit higher thermal stability, making them more tolerant to mutations, and potentially more evolvable.
However, to date, very few ancestors have been resurrected, and the experimental methodologies are still lacking. I ai…
WEIZMANN INSTITUTE OF SCIENCE
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