CORDIS Project
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This project investigates the interactions between the ribosome-translocon complex and the signal peptidase complex during protein synthesis at the endoplasmic reticulum. It employs advanced imaging techniques to explore how different translocon variants influence polysome topology and aims to achieve high-resolution s…
The human proteome is primarily synthesized at the endoplasmic reticulum (ER) membrane through the ribosome-translocon complex.
This assembly is crucial for protein synthesis, translocation, membrane insertion and post-translational modification.
Depending on the type of protein being synthesized, the translocon adopts either a secretory (soluble proteins) or multipass (membrane proteins) form.
Newly synthesized proteins often carry a signal peptide that is cleaved by the signal peptidase comple…
UNIVERSITEIT UTRECHT
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