CORDIS Project
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This project focuses on designing new functional proteins by recombining fragments of existing proteins. By identifying common structural fragments, the aim is to create stable hybrid proteins that can provide insights into protein structure, function, and evolution, with applications in synthetic biology and bioengine…
Proteins are ubiquitous, very diverse, and participate in virtually every cellular process.
Nature has generated this impressive set of proteins using mechanisms such as recombination of smaller, sub-domain sized protein fragments that serve as building blocks in a Lego-like manner.
Based on these observations we propose a rational design strategy in which new functional proteins are build from fragments of existing proteins.
With this approach we aim to tackle a long-standing goal in biochemist…
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