CORDIS Project
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The project focuses on enhancing gene editing technologies by profiling programmable nucleases to improve their specificity and safety. It aims to develop tools that allow for precise gene editing while minimizing off-target effects, ultimately benefiting applications in genetic disease treatment and diagnostics.
Programmable nucleases reside at the nexus of advanced gene editing and microbial defense.
These nucleases degrade phage DNA but avoid genomic DNA to provide the microbe with adaptive immunity.
The standard-bearer, CRISPR-Cas9, relies on a guide RNA (gRNA) – its program – to precisely cut a complimentary genetic sequence – its target – for precision gene editing.
These programmable nucleases deliver cure for genetic diseases like anemia, blindness, and cancer; quick disease model development; an…
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