CORDIS Project
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This project investigates how environmental toxins like arsenic disrupt protein folding, contributing to neurodegenerative diseases. It focuses on the roles of specific proteins, AIRAP and AIRAPL, in protecting cells from damage caused by misfolded proteins and aims to identify biomarkers for exposure and potential the…
Protein folding plays an important role in a number of neurodegenerative conditions, such as parkinson's, alzheimer's and motor neuron diseases.
Accumulating evidence suggests that environmental agents may contribute to the pathology of these common disorders by perturbing protein folding, either directly or indirectly through their effects on cell metabolism.
However, little is known how cells adapt to the threat of environmentally-induced proteotoxicity.
This study will exploit arsenic as a mo…
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