CORDIS Project
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This project explores the roles of protease-activated receptors in cardiovascular development and endothelial barrier function. It aims to uncover new developmental roles for these receptors and their interactions with lipid signaling pathways.
Protease- activated receptors (PARs) comprise a family of four G-protein coupled receptors that mediate cellular responses to proteases. PARs were identified in a search for the platelet receptor for the coagulation protease thrombin.
Mouse deficiency models later established critical roles for PARs in hemostasis and thrombosis and in vascular development, yet unexplained functions ascribed to proteases hinted at a broader functional repertoire.
To uncover new roles for PARs, we addressed redund…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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