CORDIS Project
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This project investigates the binding mechanisms of DNA binding proteins, particularly transcription factors, using structural bioinformatics. By predicting protein-DNA interactions, it aims to enhance our understanding of gene regulation and assist in genome annotation.
A major challenge in post genome biology is the functional assignment of gene products.
An important goal is the identification and characterization of DNA binding proteins – especially transcription factors – and of their specific target sequences.
Recent strategies for determining protein-DNA binding specificities combine experimental high throughput data with bioinformatics algorithms providing encouraging results.
Structure based approaches are particularly promising, as they can predict pre…
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