CORDIS Project
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The Prot-RAN project investigates the expansion of CGG repeats in the FMR1 gene, which is linked to fragile X-associated tremor/ataxia syndrome. It aims to understand the role of proteins involved in the repeat-associated non-AUG initiated translation mechanism, utilizing advanced proteomics and RNA biology techniques…
The short tandem repeats are common in human genome, but their uncontrolled expansions may lead to several inherited disorders.
In Prot-RAN project, I will focus on the expansion of trinucleotide CGG repeats (CGGexp) in the 5’UTR of fragile X mental retardation 1 (FMR1) gene, which causes common neurodegenerative disease, known as fragile X-associated tremor/ataxia syndrome (FXTAS).
The pathogenesis of FXTAS remains unclear, and one of the possible mechanisms, the repeat associated non-AUG init…
UNIWERSYTET IM. ADAMA MICKIEWICZA WPOZNANIU
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