CORDIS Project
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This project investigates mechanisms of immune tolerance to prevent autoimmune diseases, focusing on the role of dendritic cells and lymph node stromal cells in presenting self-antigens. It aims to understand how these cells influence T cell responses.
Immunological tolerance to self is essential in the prevention of autoimmune disease.
Although central tolerance is remarkably efficient, potentially autoaggressive T cells can reach the periphery.
Peripheral mechanisms of tolerance induction are therefore required to protect peripheral tissues from autoimmune attack.
The two main types of dendritic cells (DC) are conventional DC (cDC) and plasmacytoid DC (pDC), both derived from the hematopoietic lineage.
The prevailing model for peripheral tol…
UNIVERSITE DE GENEVE
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