CORDIS Project
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This project investigates PIK3CA-related overgrowth spectrum (PROS), focusing on the cellular and molecular mechanisms behind its development. By utilizing genetically modified mice, the research aims to identify specific alterations caused by PIK3CA mutations and their impact on disease progression, ultimately contrib…
PIK3CA-related overgrowth spectrum (PROS) is a group of rare congenital disorders that manifest as complex syndromes with overgrowth of several tissues (vasculature, adipose and muscle tissues, bones, brain and skin among others) or as localized lesions such as vascular malformations. PROS is caused by somatic activating mutations in the PIK3CA gene that arise postzigotically during embryonic development.
Patients suffer dramatic functional and life-threatening complications and typically requir…
INSTITUT JOSEP CARRERAS - CERCA
FUNDACIO INSTITUT DE RECERCA CONTRA LA LEUCEMIA JOSEP CARRERAS
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