CORDIS Project
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This research investigates the role of the furin protein in T cells and its impact on immune responses. By examining furin's mechanisms, the project aims to understand its involvement in autoimmune diseases and the regulation of immune responses against pathogens.
Backgound:
Interleukin (IL)-12 induced T helper (Th) 1 polarization is critical for adequate cell-medated immune responses against intracellular pathogens such as M. tuberculosis.
To gain insights into Th1 type immunity I performed a genome wide analysis for IL-12 target genes.
The results unequivocally identified proprotein convertases (PC) furin as a novel IL-12/Stat4 target gene.
Furin has been previously linked to the pathogenesis of several diseases including metastatic cancers, cystic fibr…
TAMPEREEN YLIOPISTO
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